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Abstract Introduction Cardiac complications in dengue patients are not uncommon and are not diagnosed, since they are usually mild and self-limiting. Objectives To characterize the cardiovascular manifestations in hospitalized patients with dengue infection. Methods We conducted an observational, analytical, longitudinal, prospective epidemiological study, which included 427 patients treated at Manuel Fajardo Clinical-Surgical Teaching Hospital with diagnosis of dengue infection since April 2017 to April 2018. Results Cardiovascular manifestations (19.7%), mainly heart rate disorders (sinus bradycardia [13.8%], atrial [4.9%] and ventricular [4.0%] extrasystoles) were frequent in dengue infection patients. Pericarditis and myocarditis were diagnosed in 1.6% and 0.2% respectively. These disorders were self-limiting in 83.3% of cases and occurred in the first days of the onset of fever in 75.0%. Advanced age (OR = 1.70), male sex (OR = 1.94), decreased platelet count (OR = 1.13) and dengue with warning signs (OR = 3.29) were related to a higher probability of presenting cardiovascular disorders in the course of a dengue infection. Conclusions Cardiovascular manifestations in dengue patients are frequent, and are related to advanced age, male sex, as well as severe forms of the disease.