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Enulosides, carbohydrate derivatives containing an α,β-unsaturated carbonyl unit, were designed and obtained in high yields and isomeric purity. All synthesized compounds exhibited antitumoral activity in micromolar range against four tested… Click to show full abstract
Enulosides, carbohydrate derivatives containing an α,β-unsaturated carbonyl unit, were designed and obtained in high yields and isomeric purity. All synthesized compounds exhibited antitumoral activity in micromolar range against four tested tumor cells lines, being the best results observed for HL-60 cells. These compounds open new possibilities to prepare an array of more active, site-specific or selective antitumor agents. 2016 Elsevier Ltd. All rights reserved.
Keywords:
design synthesis;
antitumoral evaluation;
synthesis antitumoral;
evaluation enulosides;
structure based;
based design
Journal Title: European journal of medicinal chemistry
Year Published: 2017
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Journal Title: European journal of medicinal chemistry
Year Published: 2017
Link to full text (if available)
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recommendations!