LAUSR

Background Estimation of left ventricular volumes, including ejection fraction (LVEF), is important in the diagnosis and the determination of severity of different cardiac diseases. Echocardiography and cardiac magnetic resonance imaging are clinically used for this purpose. However, myocardial perfusion imaging (MPI) is widely used in the diagnosis of ischemic heart disease, and the assessment of left ventricular volumes can improve the diagnostic accuracy in those patients. Development of single photon emission tomography SPECT with cadmium zinc telluride detector has improved image resolution as compared to standard sodium iodide SPECT camera. Does this improved image resolution affect quantitative assessment of left ventricular volume in MPI studies? In this study, assessment of left ventricle volumes end-diastolic and end-systolic (EDV, ESV) as well as LVEF is compared in images from three modalities. Methods A cohort of 65 patients including 29 men, and 36 women underwent echocardiography and MPI within one month at the clinical physiology department at Sahlgrenska university hospital, from January 2015 to October 2016. Among 65 patients 23 of them were excluded due to atrial fibrillation or low echocardiographic image quality, only 24 were scanned using heart dedicated scanner (DSPECT Spectrum Dynamics Medical®, and 21 were scanned using dual head SPECT (Philips ADAC Skylight® camera. Quantitative software QGS&QPS (Cedars-Sinai Medical Centre®) was used for the assessment of EDV, ESV and LVEF in MPI images. Correlation for assessment of EDV, ESV and LVEF between echocardiography versus standard SPECT camera and echocardiography versus cardiac dedicated scanner were measured with Pearson correlation coefficient. Results Comparison between echocardiography versus SPECT showed a strong positive correlation for assessment of ESV (r = 0,95, p  Conclusion Preliminary results from this patient study shows, that quantitative assessment from dedicated cardiac scanner with solid state detector underestimate ESV as a result LVEF is overestimated in MPI studies as compared to echocardiography.