LAUSR

&NA; Our hypothesis is that melt extrusion is a more suitable processing method than spray drying to prepare amorphous solid dispersions of drugs with a high crystallization tendency. Naproxen‐povidone K25 was used as the model system in this study. Naproxen‐povidone K25 solid dispersions at 30% and 60% drug loadings were characterized by modulated DSC, powder X‐ray diffraction, FT‐IR, and solid‐state 13C NMR to identify phase separation and drug recrystallization during processing and storage. At 30% drug loading, hydrogen bond (H‐bond) sites of povidone K25 were not saturated and the glass transition (Tg) temperature of the formulation was higher. As a result, both melt‐extruded and spray‐dried materials were amorphous initially and remained so after storage at 40 °C. At 60% drug loading, H‐bond sites were saturated, and Tg was low. We were not able to prepare amorphous materials. The initial crystallinity of the formulations was 0.4% ± 0.2% and 5.6% ± 0.6%, and increased to 2.7% ± 0.3% and 21.6% ± 1.0% for melt‐extruded and spray‐dried materials, respectively. Spray‐dried material was more susceptible to re‐crystallization during processing, due to the high diffusivity of naproxen molecules in the formulation matrix and lack of kinetic stabilization from polymer solution. A larger number of crystalline nucleation sites and high surface area made the spray‐dried material more susceptible to recrystallization during storage. This study demonstrated the unique advantages of melt extrusion over spray drying for the preparation of amorphous solid dispersions of naproxen at high drug level. Graphical abstract Figure. No caption available.