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Jelly containing composite based on &agr;‐glucosyl stevia and polyvinylpyrrolidone: Improved dissolution property of curcumin

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&NA; Curcumin (CUR) solutions prepared with &agr;‐glucosyl stevia (Stevia‐G) and polyvinylpyrrolidone K‐30 (PVP) by evaporation method showed 11,000‐fold higher solubility compared to CUR alone. Tri‐component formulations of CUR/Stevia‐G/PVP in aqueous… Click to show full abstract

&NA; Curcumin (CUR) solutions prepared with &agr;‐glucosyl stevia (Stevia‐G) and polyvinylpyrrolidone K‐30 (PVP) by evaporation method showed 11,000‐fold higher solubility compared to CUR alone. Tri‐component formulations of CUR/Stevia‐G/PVP in aqueous solution showed improved CUR stability for precipitation‐triggering conditions of CUR, such as aqueous dilution and temperature changes. Fluorescence study with CUR and pyrene indicated that Stevia‐G/PVP mixed solutions produce a more hydrophilic microenvironment around their molecules with increasing PVP concentration compared to Stevia‐G solution alone. These results suggested the composite formation associated with the adsorption of the aggregated structure of Stevia‐G onto PVP molecules. Jelly formulations were prepared with &kgr;‐carrageenan, and jelly formulations containing nanocomposites formed by CUR/Stevia‐G/PVP obviously enhanced the dissolution properties of CUR compared to CUR powder. This result indicated that the composite formed by CUR/Stevia‐G/PVP could be maintained even after the preparation of jelly and release into a dissolution media. Production of jelly formulations using Stevia‐G and PVP are a promising way to improve the dissolution properties of CUR. Graphical abstract Figure. No caption available.

Keywords: stevia; glucosyl stevia; stevia pvp; agr glucosyl; dissolution; pvp

Journal Title: European Journal of Pharmaceutical Sciences
Year Published: 2018

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