LAUSR

C1Q, C1Q nephropathy; eGFR, estimated glomerular filtration rate; FSGS, focal segmental glomerulosclerosis; HSP, Henoch-Schonlein purpura; IgAN, IgA nephropathy; IgAV, IgA vasculitis; inc., including; IQR, interquartile range; MCD, minimal change disease; MN, membranous nephropathy; UPCR, urine protein-to-creatinine ratio. P values from c test for categorical variables and t tests for continuous variables. UPCR was log transformed before testing. To the Editor: Primary glomerulonephropathies (GNs) and preeclampsia share a common phenotype of proteinuria, hypertension, and renal dysfunction. Precise mechanisms for these disease manifestations in each setting are not fully elucidated; however, both preeclampsia and active glomerular disease are associated with podocyturia and altered expression of podocyte-specific proteins. Preeclampsia may lead to immediate adverse pregnancy outcomes and also increases the odds of developing cardiovascular disease and end-stage renal disease. Given the epidemiologic and hypothesized pathophysiologic parallels between glomerular disease and hypertensive disorders of pregnancy, we studied a cohort of patients with biopsy-proven GN (Cure Glomerulonephropathy) to assess whether preeclampsia, proteinuria, worsening hypertension, or decreased kidney function (“renalrelevant complications”) during a first pregnancy altered the timing and nature of the subsequent GN presentation. Missingness (no complications n, any complications n): eGFR (51,8); UPCR (78,16).