LAUSR

&NA; The objective of the present study was investigation of the selenium (Se) levels in environmental samples, main consumed food products, as well as human hair in the areas of the Orenburg region. Se levels in the environmental objects (water, soil, wheat), frequently consumed food products (wheat bread, ryebread, beef, pork, chicken, milk, cottage cheese), as well as human hair samples in the western (n = 210), central (n = 195), and eastern (n = 120) areas were assessed using inductively‐coupled plasma mass‐spectrometry and atomic absorption spectrometry (soil). The obtained data demonstrate that water (87% and 89%), soil (41% and 48%), and wheat (11% and 11%) Se levels Central and Eastern areas were significantly higher than those in the Western area. The level of Se in foods was found to be the highest in the Eastern (wheat bread and beef), Central and Eastern (ryebread and pork), or Central (milk and cottage cheese) areas of the Orenburg region. Hair Se content (0.298 (0.233–0.591) &mgr;g/g) as well as dietary Se intake (84.3 (73.7–95.8) &mgr;g/day) did not differ significantly between the studied areas. At the same time, regression analysis demonstrated that Se intake with wheat bread (&bgr; = 0.634; p = 0.042) was the strongest predictor of hair Se. The revealed associations between environmental and food Se content and Se status of the population underline the necessity of continuous monitoring of Se intake and exposure in order to prevent potential health effects associated with both deficiency and overload. Graphical abstract Figure. No caption available. HighlightsEnvironmental, food, and hair Se levels were studied using ICP‐DRC‐MS.Environmental Se levels were higher in the industrially developed eastern area.Se levels in environmental and food samples were lowest in the western area.No geographic difference in hair Se content was revealed.Wheat, ryebread, and milk Se levels were significant predictors of hair Se.