LAUSR

OBJECTIVE The purpose of this study is to localize the sources of epileptiform discharges (EDs), in juvenile myoclonic epilepsy (JME) using Magnetoencephalography (MEG), at three different time instances and analyze the propagation of EDs, from onset to offset, for inferring the cortical and subcortical region of involvement. METHODS Twenty patients (age 23.5±6.3years old) with JME were recruited in this prospective study. MEG source analysis was performed on the independently collected EDs of each patient. The distributed source model was employed for source localization using low resolution electromagnetic brain tomography (LORETA). In each EDs, the onset (leading edge of the spike from baseline), peak and offset (trailing edge of the spike), with time window of 8ms, were subjected for source localization in order to study the propagation of the EDs. The obtained source location coordinates, from each individual MRI, were transformed in Talairach space and the distribution of region of source involvement was analysed. RESULTS The frequency pattern of lobar distribution at onset, peak and offset respectively suggest that discharges most commonly localized at onset from sublobar region, at peak from frontal lobe and at offset from the sublobar region. It was observed that the maximum involvement of sources from the sublobar, limbic and frontal lobes at different time instances. It indicates that the restricted cortical-subcortical involvement during the generation and propagation of EDs in JME. SIGNIFICANCE This MEG study supported the cortical-subcortical region of involvement and provided further insights in our understanding the network involvement in generation and propagation of EDs in JME.