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Commentary on “High incidence of persistent sub-therapeutic levels of most common AEDs in children with epilepsy receiving polypharmacy”

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The paper by Czornyj et al. accepts the hypothesis that non-compliance/non-adherence to a therapeutic regimen may well explain the presence of low antiepileptic medication (AEM) blood levels in ambulatory patients… Click to show full abstract

The paper by Czornyj et al. accepts the hypothesis that non-compliance/non-adherence to a therapeutic regimen may well explain the presence of low antiepileptic medication (AEM) blood levels in ambulatory patients but does not accept this as an explanation for low levels in patients who are admitted to hospital, The paper explores blood levels of the most commonly used AEMs, namely phenytoin (PHT), phenobarbitone (PHB), valproate (VPA) and carbamazepine (CBZ). It demonstrated higher rates of low PHT levels than was the case for PHB, VPA or CBZ.

Keywords: sub therapeutic; high incidence; commentary high; incidence persistent; persistent sub; therapeutic levels

Journal Title: Epilepsy Research
Year Published: 2018

Link to full text (if available)


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