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Metastatic urothelial carcinoma to the liver with unknown primary tumor

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Cancer of unknown primary (CUP), a rare and aggressive clinical entity, accounts for approximately 3% of all malignancies. CUP with urothelial origin is even more unusual, with no other cases… Click to show full abstract

Cancer of unknown primary (CUP), a rare and aggressive clinical entity, accounts for approximately 3% of all malignancies. CUP with urothelial origin is even more unusual, with no other cases reported in the current literature. As imaging and other studies often do not reveal the tumor origin, the approach to CUP involves a focused search for the primary tumor, relying on guidance from immunohistochemical staining of biopsy specimens. Treatment consists of standard therapies directed at the most likely tumor origin.

Keywords: carcinoma liver; primary tumor; unknown primary; urothelial carcinoma; metastatic urothelial; tumor

Journal Title: Urology Case Reports
Year Published: 2019

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