Abstract Introduction Jie Yu Dan(JYD), a traditional Chinese medicine, is used to promote circulation and has been used for people experiencing speech and language difficulties with post-stroke aphasia. The objectives… Click to show full abstract
Abstract Introduction Jie Yu Dan(JYD), a traditional Chinese medicine, is used to promote circulation and has been used for people experiencing speech and language difficulties with post-stroke aphasia. The objectives of this study were to systematically evaluate randomized clinical trials (RCTs) to assess the efficacy of JYD for improving post-stroke aphasia. Methods All RCTs that studied JYD treatment in post-stroke aphasia were selected from English, Korean and Chinese language databases until February 2018. Studies of participants with post-stroke aphasia were divided into 2 groups that had common treatments with JYD and placebo or Western medicine, respectively. Risk ratio and mean differences with 95% confidence intervals (CI) were calculated for the pooled RCTs with a fixed or random model in the meta-analysis. Since the RCTs had some heterogeneity in JYD prescriptions, duration of the therapy and the control group, some subgroup analysis was conducted. Risk of bias and publication bias was assessed for all included RCTs. Results The JYD with conventional therapy (n = 439) additionally improved the overall efficacy of post-stroke aphasia by 1.34 fold in comparison to the conventional therapy (n = 370) in the fixed effect model including 10 RCTs(P Conclusions JYD might improve the efficacy of conventional therapy and/or acupuncture for treating post-stroke aphasia considering the quality of RCTs included. However, larger and highly controlled RCTs are needed to confirm the results.
               
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