LAUSR

Abstract Introduction Psoriasis is an inflammatory and proliferative disease. Indigo naturalis is a blue herbal pigment extracted from Indigofera tinctoria and other plants. The purpose of this study was to compare Iranian ointment made of Indigofera tinctoria with Chinese ointment made of Indigo naturalis from China, and topical betamethasone on the severity of chronic plaque-type psoriasis. Methods In this preliminary randomized double-blind pilot study, patients with localized chronic plaque-type psoriasis were divided into three groups to receive either topical Iranian herbal ointment, Chinese herbal ointment, or betamethasone ointment twice a day for 8 weeks. Results At the end of the 8th week of treatment, the mean PASI score in the three groups was 5.8 ± 3.13, 6.32 ± 2.85, 3.04 ± 2.23 for the Chinese, Iranian and betamethasone ointments respectively; and the mean PASI score change from baseline was statistically significant only in the topical betamethasone group (p = 0.0082). Conclusion The Iranian herbal ointment used for psoriasis for 8 weeks caused a lower clinical response in comparison with topical betamethasone or the Chinese herbal ointment in the studied patients.