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Vat photopolymerization of liquid, biodegradable PLGA-based oligomers as tissue scaffolds

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Abstract Additive manufacturing (AM) of tissue scaffolds provides medical professionals and patients with personalized treatment options, which align with patients’ specific physiology and provide a more efficient and precise manufacturing… Click to show full abstract

Abstract Additive manufacturing (AM) of tissue scaffolds provides medical professionals and patients with personalized treatment options, which align with patients’ specific physiology and provide a more efficient and precise manufacturing process. Vat photopolymerization (VP) AM affords biocompatible, degradable, and high-resolution scaffolds capable of achieving specific pore sizes necessary for tissue regeneration. Earlier biodegradable, photoactive polymers for the VP platform usually require dissolution in a solvent or water, which often results in anisotropic shrinkage upon drying and inconsistencies in the final part geometry. This work describes a photoactive oligomeric precursor that eliminates the requirement for water or solvent during VP. Poly(lactide-co-glycolide) (PLGA) diacrylates with low number-average molecular weights (

Keywords: vat photopolymerization; photopolymerization liquid; liquid biodegradable; tissue scaffolds; plga

Journal Title: European Polymer Journal
Year Published: 2020

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