LAUSR

Experts’ summary: The authors identified 1433 men with prostate cancer (PCa) in an active surveillance (AS) program at their institution. Median follow-up was 49 mo and 42% of patients were aged 60 yr. The biopsy-based Gleason score upgrade-free rate was 73% at 3 yr and 55% at 5 yr for men aged 60 yr, compared to 64% and 48%, respectively, for men aged 60 yr (p < 0.01). Younger age was independently associated with a lower risk of Gleason score upgrading. In addition, there was no association between younger age and risk of definitive treatment or biochemical recurrence after delayed radical prostatectomy. The authors concluded that after appropriate risk stratification, patients may be counseled that outcomes are similar among younger and older patients in the intermediate term.