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Acute myeloid leukemia xenograft success prediction: Saving time

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HIGHLIGHTS • Extracellular phenotype, apoptosis, or cell cycle profile at thawing cannot predict acute myeloid leukemia (AML) xenograft potential.• Leukemic long-term culture-initiating cell content distinguishes fast and delayed engraftment potential.•… Click to show full abstract

HIGHLIGHTS • Extracellular phenotype, apoptosis, or cell cycle profile at thawing cannot predict acute myeloid leukemia (AML) xenograft potential.• Leukemic long-term culture-initiating cell content distinguishes fast and delayed engraftment potential.• Defined here is a 1-week carboxyfluorescein succinimidyl ester-based assay that predicts AML xenograft success.

Keywords: myeloid leukemia; xenograft; xenograft success; acute myeloid

Journal Title: Experimental Hematology
Year Published: 2018

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