Photo by nci from unsplash
Non-random chromosomal translocations involving the putative transcription factor, Mixed Lineage Leukemia Translocated to, 10 (MLLT10, also known as AF10) are commonly observed in both acute myeloid and lymphoid leukemias, and… Click to show full abstract
Non-random chromosomal translocations involving the putative transcription factor, Mixed Lineage Leukemia Translocated to, 10 (MLLT10, also known as AF10) are commonly observed in both acute myeloid and lymphoid leukemias, and are indicative of a poor prognosis. Despite the well described actions of oncogenic MLLT10 fusion proteins, the role of wild type MLLT10 in hematopoiesis is not well characterized. The protein structure and several interacting partners have been described, and give indications as to the potential functions of MLLT10. This review examines these aspects of MLLT10, contextualizing its function in benign and malignant hematopoiesis.
Journal Title: Experimental hematology
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!