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Highlights • A RUNX1/RUNX1T1-associated gene expression network drives acute myeloid leukemia.• RUNX1/RUNX1T1 dysregulates gene expression at multiple levels.• Interrogation of the RUNX1/RUNX1T1 network by RNA interference or CRISPR screens identifies… Click to show full abstract
Highlights • A RUNX1/RUNX1T1-associated gene expression network drives acute myeloid leukemia.• RUNX1/RUNX1T1 dysregulates gene expression at multiple levels.• Interrogation of the RUNX1/RUNX1T1 network by RNA interference or CRISPR screens identifies novel therapeutic targets.• RUNX1/RUNX1T1 drives cell cycle progression in G1 by promoting CCND2 and CDK6 expression.• RUNX11/RUNX1T1-positive AMLs are sensitive toward CDK4/6 inhibitors.
Keywords:
network translating;
runx1 runx1t1;
runx1t1 network;
translating insights;
runx1t1
Journal Title: Experimental Hematology
Year Published: 2020
Link to full text (if available)
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Journal Title: Experimental Hematology
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!