LAUSR

Abstract It can be deduced from this concise review that bradykinin and polyphenols could have a double role in health. Nevertheless, if their bioavailability is improved by their encapsulation, polyphenols could diminish the binding affinity of bradykinin to its receptors by causing a conformational rearrangement of the peptide. Besides, the interaction between polyphenols and bradykinin should play a role in pain. Indeed, the formation of the polyphenol-bradykinin aggregates might alleviate the pain sensation caused by bradykinin by preventing: the production of nitric oxide, the activation of phospholipase A2, as well as that of nuclear factor-kappa B. To conclude, this work falls within the basic science, given that it seeks to provide a probable biochemical mechanism of the pharmacological action of polyphenols on the pain sensation caused by bradykinin.