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Blastocyst collapse and downgrading of inner cell mass morphology score after vitrification-warming is predictive of reduced implantation and increased early pregnancy loss

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The ability to cryopreserve and genetically screen embryos has increased cumulative pregnancy rates and confidence in embryo banking. Compared to fresh ET cycles, endometrial receptivity and placentation appear to be… Click to show full abstract

The ability to cryopreserve and genetically screen embryos has increased cumulative pregnancy rates and confidence in embryo banking. Compared to fresh ET cycles, endometrial receptivity and placentation appear to be enhanced by the more physiologic hormonal milieu of FET cycles. Whether the influence of vitrification-warming on the morphology of euploid blastocysts impacts their implantation potential is not well characterized. This study examines whether changes in morphology grading, after vitrification-warming, correlate with clinical outcome, using a study model controlling for endometrial environment and embryonic ploidy.

Keywords: pregnancy; morphology; implantation; vitrification; vitrification warming; blastocyst collapse

Journal Title: Fertility and Sterility
Year Published: 2017

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