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OBJECTIVE: Caseinolytic peptidase P (CLPP) mediates degradation of mitochondrial misfolded proteins to maintain homeostasis under metabolic stress. CLPP is a key factor for mitochondrial function and targeted global germline deletion… Click to show full abstract
OBJECTIVE: Caseinolytic peptidase P (CLPP) mediates degradation of mitochondrial misfolded proteins to maintain homeostasis under metabolic stress. CLPP is a key factor for mitochondrial function and targeted global germline deletion of Clpp results in female infertility and accelerated follicular depletion. In this study, we aimed to determine the mechanism of reproductive dysfunction in this model, by investigating molecular and ultrastructural changes that take place in cumulus cells lacking CLPP.
Journal Title: Fertility and Sterility
Year Published: 2018
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