LAUSR

Objective: Methylenetetrahydrofolate reductase (MTHFR) plays an important role in catalyzing the conversion of 5, 10 methylenetetrahydrofolate into 5-methylenetetrahydrofolate, the predominant circulating form of folate in humans. Variations in the sequence of MTHFR gene have been implicated in the sub-fertile population and may influence embryo development, implantation and aneuploidy rates. Additionally, the viability of euploid embryo may suffer as a result of potential MTHFR gene polymorphism’s effect on multiple essential processes including meiosis, embryogenesis and pregnancy initiation. (Enciso M, et al. 2016). This study seeks to analyze the proportion and odds of embryo aneuploidy in patients detected as carriers of the most common types of MTHFR gene mutations.