LAUSR

OBJECTIVE: Sperm cryopreservation is a widespread tool in assisted reproduction for the management of male infertility and it is mandatory for sperm donor programs. It is wellestablished that cryopreservation causes loss of sperm motility, impacting on its reproductive competence. Therefore, the selection of sperm donor samples with good freezability and fertilization abilities is important for optimization of sperm banks. The molecular basis of the vulnerability to cryopreservation is still unknown. Microarray provides a powerful tool to explore the molecular mechanisms involved in cryoinjury. The objective of this study is to characterize the gene expression profiles of semen samples according to their resistance to cryopreservation and to determine the impact of cryodamage on pregnancy outcomes after donor intrauterine insemination (IUI).