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Four new monoterpenoid indole alkaloids (MIAs), scholarisines P-S (1-4), and 14 known MIAs (5-18) were isolated from the leaves of Alstonia scholaris (L) R. Br. (Apocynaceae). Their structures were elucidated… Click to show full abstract
Four new monoterpenoid indole alkaloids (MIAs), scholarisines P-S (1-4), and 14 known MIAs (5-18) were isolated from the leaves of Alstonia scholaris (L) R. Br. (Apocynaceae). Their structures were elucidated by analyzing their HRESIMS data and NMR spectroscopic data. All of the isolated MIAs were evaluated for their Nuclear Factor-kappa B (NF-κB) inhibitory activity in HepG2-NF-κB-Luc cells. Among them, five compounds (4, 7, 8, 13 and 16) exhibited significant NF-κB inhibitory activity.
Keywords:
alstonia scholaris;
leaves alstonia;
indole alkaloids;
inhibitory activity;
activity;
monoterpenoid indole
Journal Title: Fitoterapia
Year Published: 2018
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Journal Title: Fitoterapia
Year Published: 2018
Link to full text (if available)
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recommendations!