Chemical investigation of Euphorbia helioscopia resulted in the identification of seven new triterpenes named euphorbatrine A-G (1-7), including two (19αH)-lupane (1-2) and three (9βH)-lanostane (4-6), which are very rare metabolites… Click to show full abstract
Chemical investigation of Euphorbia helioscopia resulted in the identification of seven new triterpenes named euphorbatrine A-G (1-7), including two (19αH)-lupane (1-2) and three (9βH)-lanostane (4-6), which are very rare metabolites from plants. Their structures were elucidated by extensive spectroscopic analysis, X-ray crystallography and chemical methods. Compounds 5 and 6 triggered apoptosis of Hela-/- cell with EC50 values of 1.59±0.25 and 26.48±0.78μM, respectively.
Keywords:
lanostane triterpenes;
lupane lanostane;
apoptosis;
lanostane;
cell;
euphorbia helioscopia
Journal Title: Fitoterapia
Year Published: 2018
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Journal Title: Fitoterapia
Year Published: 2018
Link to full text (if available)
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recommendations!