LAUSR

Abstract Emulsions containing unsaturated fatty acids (UFAs) have potential in the treatment of clinical malnutrition. However, the stability of UFAs is a major problem due to the presence of double bonds, which are susceptible to oxidation, leading to the loss of nutrition and even resulting in side effects. The factors that affect the UFAs are complex, and the protective effect of single antioxidant is not satisfactory. The goal of the study was the development of UFA-enriched oil-in-water (O/W) emulsions with improved stability, simultaneously employing a hydrophilic (catechol) and a hydrophobic (tocopherol) antioxidant, and then to investigate the stabilization mechanisms of catechol and tocopherol for emulsions. The emulsions obtained in this study showed uniform nanoscale droplets and good storage stability for three months under accelerated conditions. More than 93.0% of fatty acids remained unchanged after six months of storage, which demonstrated the protective effects of catechol and tocopherol. The dual antioxidant emulsions were remarkably effective in protecting the UFAs compared to emulsions with a single antioxidant or without any antioxidant. This dual antioxidant emulsion system provides new opportunities for the transmission of oxidation-prone nutrients, and its prospects are optimistic.