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Recent methamphetamine profiling trends: Tracking the nitrostyrene method used for P2P production

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Abstract N-butylamphetamine and N-cyclohexylamphetamine have been found to be useful target compounds for tracking P2P-based methamphetamine produced using nitrostyrene chemistry. Since 2015, these two process impurities have been detected at… Click to show full abstract

Abstract N-butylamphetamine and N-cyclohexylamphetamine have been found to be useful target compounds for tracking P2P-based methamphetamine produced using nitrostyrene chemistry. Since 2015, these two process impurities have been detected at low levels in many seized methamphetamine samples and forensic information regarding these target compounds is provided in this report. Several laboratory experiments were performed using a variety of nitrostyrene related conditions to synthesize P2P. Methamphetamine was then produced using standard reductive amination conditions to prove that the presented target impurities were detected and therefore related to nitrostyrene chemistry. Methamphetamine profiling data is then presented to show that nitrostyrene related profiles have been dominant in the United States for the last 3 years.

Keywords: recent methamphetamine; methamphetamine; p2p; profiling trends; chemistry; methamphetamine profiling

Journal Title: Forensic Chemistry
Year Published: 2019

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