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Ovarian cancer is comprised of multiple histological subtypes that vary widely in metabolic phenotypes. Moreover, metabolic flexibility is required to sustain survival in different tumor niches during metastatic progression in… Click to show full abstract
Ovarian cancer is comprised of multiple histological subtypes that vary widely in metabolic phenotypes. Moreover, metabolic flexibility is required to sustain survival in different tumor niches during metastatic progression in the peritoneal cavity. For example, colonization of omental adipose tissues requires alterations in lipid transport, synthesis and metabolism. We previously identified a novel regulator of lipid metabolism, myelin protein zero-like 3 (MPZL3), using Mpzl3 knockout mice and C57BL/6N mice treated with Mpzl3 antisense oligonucleotides (ASO). Loss of Mpzl3 resulted in reduced adiposity, decreased serum triglycerides and cholesterol, and reduced hepatic lipid synthesis. Indirect calorimetry revealed a significant decrease in respiratory exchange ratios with Mpzl3 ASO treatment (p
Journal Title: Free Radical Biology and Medicine
Year Published: 2017
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