LAUSR

The main purpose of our study was to investigate the oxidative modifications of proteins in blood of patients with nephropathies of various origins. There were 80 patients divided into 4 groups depending on the type of nephropathy. 1st group was represented by patients with acute alcoholic nephropathy; the 2nd group - by patients with nephropathy caused by acute poisoning with alcohol surrogates; in the 3th group pregnant women with gestosis were included; the 4th group – was represented by patients with acute medication nephropathy (acute drug poisoning). The control group consisted of 15 healthy subjects. The reactive protein carbonyl derivatives were detected in plasma and erythrocytes (Levine et.al, 1990), advanced oxidation protein products (AOPP) were detected in serum (Witko-Sarsat et al., 1996). In blood plasma of patients of 1–4 groups the concentration of reactive protein carbonyl derivatives was lower in comparison with control ones (p