LAUSR

The metabolic syndrome is an important health problem affecting approximately 20–30% of the adult population in many countries. Metabolic syndrome (MS) is a life-threatening syndrome in which the presence of systemic disorders such as obesity, diabetes mellitus, hypertension and coronary artery disease in the presence of insulin resistance. Nitric oxide synthase (NOS), which plays an important role in especially heart disease and catalysis NO synthesis, may be inhibited by endogenous metallarginines. ADMA appears to be the most important of these endogenous NOS inhibitors and same time endothelial dysfunction is a known atherosclerotic disease that plays a central role in the vascular disease process. In this study, it was aimed to evaluate ADMA as a marker in the detection of endothelial damage caused by oxidative stress. This study included 25 with MS and 20 healthy individuals. ADMA was determined by using HPLC. ADMA levels were statistically significantly higher than MS than healthy individuals (p