Photo from academic.microsoft.com
Systemic chemotherapy as a routine method for the treatment of cancers has several complications. Localized chemotherapy can significantly increase the treatment efficacy and reduce side effects. Here, mesenchymal stem cells… Click to show full abstract
Systemic chemotherapy as a routine method for the treatment of cancers has several complications. Localized chemotherapy can significantly increase the treatment efficacy and reduce side effects. Here, mesenchymal stem cells derived microvesicles (MVs) was incorporated into Polycaprolactone nanofibers and then the apoptotic behavior of MCF-7 breast cancer cells was investigated while cultured on MVs-Polycaprolactone by using SEM, MTT and apoptotic gene expression. Results demonstrated that MVs-Polycaprolactone group was shown a great apoptosis induction potential into MCF-7 cells and it can be concluded that MVs-Polycaprolactone has a great promising potential to introduce as an in-situ tumor inhibitor construct rather than chemo-drugs.
Journal Title: Gene
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!