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Highlights • PI3K/AKT pathway alterations are frequently seen in ovarian cancer, providing rationale for targeted AKT inhibition.• AKT inhibitor MK-2206 in platinum resistant high grade serous ovarian cancer was notable… Click to show full abstract
Highlights • PI3K/AKT pathway alterations are frequently seen in ovarian cancer, providing rationale for targeted AKT inhibition.• AKT inhibitor MK-2206 in platinum resistant high grade serous ovarian cancer was notable for dermatologic toxicity.• Best response of stable disease was seen, with one patient experiencing a prolonged SD of 19 weeks.
Keywords:
grade serous;
high grade;
inhibitor 2206;
resistant high;
akt inhibitor;
platinum resistant
Journal Title: Gynecologic Oncology Reports
Year Published: 2020
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Journal Title: Gynecologic Oncology Reports
Year Published: 2020
Link to full text (if available)
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recommendations!