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Non-gestational choriocarcinoma with hyperprogression on pembrolizumab: A case report and review of the literature

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Highlights • Non gestational choriocarcinoma is diagnosed by history, pathology, & genetics.• There is a paucity of data regarding the efficacy of immunotherapy in this disease.• Hyperprogression on immunotherapy can… Click to show full abstract

Highlights • Non gestational choriocarcinoma is diagnosed by history, pathology, & genetics.• There is a paucity of data regarding the efficacy of immunotherapy in this disease.• Hyperprogression on immunotherapy can occur in gynecologic malignancies.• Hyperprogression was associated with aberrations in the CHEK2/TP53 pathway.

Keywords: hyperprogression pembrolizumab; choriocarcinoma hyperprogression; gestational choriocarcinoma; hyperprogression; non gestational

Journal Title: Gynecologic Oncology Reports
Year Published: 2022

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