LAUSR

Purpose Bronchopulmonary dysplasia (BPD) patients have poor respiratory trajectories and are at increased risk of lung function decline with age. Lung transplantation (LTx) is a possible treatment option for this growing patient population. This study aims to determine the characteristics of BPD patients listed for LTx, and their waitlist and post-transplant outcomes. Methods The UNOS Registry was queried for patients of all ages listed for or who underwent LTx with a diagnosis of BPD between January 1987- March 2020. Descriptive analysis and waitlist outcomes were determined. Post-LTx survival at 1-, 5-, and 10-years was assessed. Post-LTx survival for patients born in the pre-surfactant era (pre-SE, before 1990) and those born afterwards (post-SE) was compared. Results BPD was reported in 64 patients of which 53.1% (n=34) were born in the pre-SE. Median age at listing was 21 years: 30.5 years pre-SE and 5 years post-SE (p 18 years) compared to 22.2% (n=4) of post-SE patients (p=0.007). 61.1% (n=11) of post-SE patients were aged ≤10 years. Post-LTx survival was 90% at 1-year, 73% at 5-years, and 46% at 10-years. Patients born post-SE trended toward better survival than pre-SE at 1-, 5- and 10-year post-LTx (p=0.11) (Figure). Conclusion BPD patients born in pre-SE received LTx as adults, whereas younger children with BPD have undergone LTx in post-SE. Importantly, post-LTx outcomes appear to be acceptable compared to other patient populations in the modern era. Thus, we recommend that patients with BPD with progressive deterioration should be considered for LTx.