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The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency… Click to show full abstract
The –1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus. This study aimed to successfully develop a toolkit for screening antiviral drugs. Finally, the FDA-approved drug library was screened, revealing that ivacaftor and (–)-Huperzine A worked well in changing the –1 ribosomal frameshifting of SARS-CoV-2 in vitro.
Keywords:
frameshifting sars;
ribosomal frameshifting;
screening toolkit;
drug screening;
sars cov
Journal Title: Heliyon
Year Published: 2020
Link to full text (if available)
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Journal Title: Heliyon
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!