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Background: Macrophages contribute to inflammatory processes occurring within the aortic wall of patients with abdominal aortic aneurysm (AAA). Macrophage function is modulated by endogenous regulatory mechanisms that include endotoxin tolerance,… Click to show full abstract
Background: Macrophages contribute to inflammatory processes occurring within the aortic wall of patients with abdominal aortic aneurysm (AAA). Macrophage function is modulated by endogenous regulatory mechanisms that include endotoxin tolerance, a phenomenon linked to aberrant Toll-like receptor 4 (TLR4) signalling. Since AAA is associated with the presence of known TLR4 activators, this study investigated the possibility that AAA macrophages exhibit an immunosuppressive phenotype reminiscent of tolerance.
Journal Title: Heart Lung and Circulation
Year Published: 2018
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