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Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis

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Highlights • Th2-type cytokine IL-33 delayed the disease onset of female SOD1-G93 A transgenic ALS mice.• IL-33 decreased the proportion of T cells in the spleens and lymph nodes of female… Click to show full abstract

Highlights • Th2-type cytokine IL-33 delayed the disease onset of female SOD1-G93 A transgenic ALS mice.• IL-33 decreased the proportion of T cells in the spleens and lymph nodes of female mice.• IL-33 decreased astrocytic activation in the spinal cord of female mice.• Male mice were unresponsive to the treatment.

Keywords: long term; treatment; astrocytic activation; disease onset

Journal Title: IBRO Reports
Year Published: 2019

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