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The effect of levomepromazine on the healthy and injured developing mouse brain – An in vitro and in vivo study

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Highlights • Levomepromazine (LMP) does not induce cell death in the healthy developing brain.• Excitotoxic lesion size and apoptosis are unaffected by LMP.• Body weight gain is reduced in mouse… Click to show full abstract

Highlights • Levomepromazine (LMP) does not induce cell death in the healthy developing brain.• Excitotoxic lesion size and apoptosis are unaffected by LMP.• Body weight gain is reduced in mouse pups receiving higher-dose LMP treatment.• Further studies are required prior to a routine use of LMP in neonates.

Keywords: effect levomepromazine; developing mouse; injured developing; healthy injured; levomepromazine healthy; brain

Journal Title: IBRO Reports
Year Published: 2020

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