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Abstract A group of new Pt(II) complexes with dichloroacetate (DCA), bearing DMSO (cis-[Pt(DCA)2(Me2SO-S)2], 2) or phosphines (cis-[Pt(DCA)2(PPh3)(Me2SO-S)], 3, cis-[Pt(DCA)2(P)2], P = PPh3 3a, P = PTA 4a and [Pt(DCA)(P)3]DCA, P = PPh3 3b, P = PTA, 4b) as… Click to show full abstract
Abstract A group of new Pt(II) complexes with dichloroacetate (DCA), bearing DMSO (cis-[Pt(DCA)2(Me2SO-S)2], 2) or phosphines (cis-[Pt(DCA)2(PPh3)(Me2SO-S)], 3, cis-[Pt(DCA)2(P)2], P = PPh3 3a, P = PTA 4a and [Pt(DCA)(P)3]DCA, P = PPh3 3b, P = PTA, 4b) as neutral ligands was prepared by a simple fast route from the inorganic synthon [PtCO3(Me2SO-S)2], 1. The X-ray crystal structures of 2, 3, 3a and 4a were determined. The antiproliferative activity of 2, 4a, and 4b was evaluated against two human cancer cell lines, cisplatin sensitive A2780 and cisplatin resistant SKOV-3, and the results were compared with known amine analogues and with the dichloride precursors.
Journal Title: Inorganica Chimica Acta
Year Published: 2018
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