LAUSR

Abstract This review is based on the analysis of recent developments on cyanation reactions for the synthesis of nitriles (RCN) through transition metal mediated cyanation reaction as well as by using non-metal like iodine (transition metal free system). In this regard, various catalyzed systems were reviewed to find the most efficient method having acceptable reaction system with surely less cost, mild conditions with easy handling. For the synthesis of nitriles; Copper, Palladium, Rhodium, and Iodine-based catalyzed systems have been explored for various aryl halides, arenes, pyridine, quinolone, imidazole, thiophenol, β -keto esters/amides, 2-arylbenzothiazoles etc. These reactions underwent with different time rates having the corresponding nitriles leading to natural products derivative in moderate to good yields.