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Facile and economical Miyaura borylation and one-pot Suzuki–Miyaura cross-coupling reaction

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Abstract Facile and economical method for Miyaura borylation reaction between B2pin2 and aryl bromides is reported. The catalytic system containing 2 mol% PdCl2(PPh3)2 and KOAc serves to enable borylations to occur… Click to show full abstract

Abstract Facile and economical method for Miyaura borylation reaction between B2pin2 and aryl bromides is reported. The catalytic system containing 2 mol% PdCl2(PPh3)2 and KOAc serves to enable borylations to occur under solvent-free and atmospheric conditions. The developed protocol can be applied to synthesize symmetrical and unsymmetrical biaryls via one-pot two-step Suzuki–Miyaura cross-coupling reaction and also offers the up-scalability.

Keywords: facile economical; miyaura borylation; reaction; one pot; suzuki miyaura; miyaura

Journal Title: Inorganica Chimica Acta
Year Published: 2020

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