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Abstract To develop novel fluorescent probes for detecting endogenous histidine (His) plays significant roles in physiological and pathological fields. Herein, a non-emissive Ir(III) complex [Ir(C–N)2(CH3CN)2]+NO3− (IrCN, C–N represents 2-phenylpyridine derivative)… Click to show full abstract
Abstract To develop novel fluorescent probes for detecting endogenous histidine (His) plays significant roles in physiological and pathological fields. Herein, a non-emissive Ir(III) complex [Ir(C–N)2(CH3CN)2]+NO3− (IrCN, C–N represents 2-phenylpyridine derivative) has been demonstrated to be a reaction-based fluorescent probe for the recognition of His in HEPES buffer. It is found that IrCN can selectively detect His with a distinct “turn-on” luminescence and low limit of detection (LOD = 0.62 μM), relying on which, IrCN can light-up the cytoplasm and nuclear region of the fixed cells, exhibiting negligible cytotoxicity and suitable solubility under test concentration.
Journal Title: Inorganica Chimica Acta
Year Published: 2020
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