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A human milk oligosaccharide, 2′-fucosyllactose, enhances the immunity in mice fed an infant formula milk diet

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Abstract The immune effect of 2′-fucosyllactose (2′FL) in mice fed an infant formula (IF) milk diet was studied. Forty-five BALB/C mice were randomly divided into 3 groups: control, and low… Click to show full abstract

Abstract The immune effect of 2′-fucosyllactose (2′FL) in mice fed an infant formula (IF) milk diet was studied. Forty-five BALB/C mice were randomly divided into 3 groups: control, and low and high dose of 2′FL. 2′FL was administered once daily for 30 days and all the mice were fed IF milk diet. On day 30, the spleen and thymus were isolated and weighed for immune organ index calculation. Natural killer (NK) cell activity, T-lymphocyte proliferation capacity and delayed-type hypersensitivity reactivity (DTH) were measured. There was a significant increase in thymus index in high dose 2′FL group (p

Keywords: infant formula; milk; fed infant; milk diet; mice fed

Journal Title: International Dairy Journal
Year Published: 2019

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