LAUSR

BACKGROUND Overt left ventricular (LV) dysfunction and congestive heart failure are known entities in Takayasu arteritis (TA). Subclinical LV dysfunction may develop in these patients despite normal LV ejection fraction (LVEF). Moreover, effect of treatment of aortic or renal artery narrowing in such patients is unknown. METHODS This study included 15 angiographically confirmed TA patients undergoing aortic and/or renal intervention. A comprehensive clinical, biochemical and echocardiographic (2-dimensional, speckle tracking and tissue doppler imaging) evaluation were done at baseline, 72 hours, and six months post intervention. RESULTS Six patients(40%) had reduced LVEF(<50%) at baseline while rest 9(60%) patients had reduced global longitudinal strain (GLS) but normal EF. Diastolic filling pattern was abnormal in all the patients. In patients with baseline reduced EF,mean EF improved from 24.62±12.14% to 45.6±9.45% (p=0.001), E/e' ratio decreased from 15.15±3.19 to 10.8±2.56 (p=0.005) and median NT pro BNP decreased from 1673pg/ml (970-2401pg/ml) to 80pg/ml (40-354 pg/ml) (p=0.001) at 6 months after interventional procedure. In patients with baseline normal EF,median NT pro BNP decreased from 512pg/ml (80-898.5pg/ml) to 34 pg/ml (29-70.8pg/ml) (p<0.01), mean GLS improved from -8.80±0.77% to -16.3±0.78%(p <0.001) and mean E/e' decreased from 12.93±2.63 to 7.8±2.73 (p=0.005) at 6 months follow up. CONCLUSION LV dysfunction is common in patients with TA and obstructive lesions in aorta or renal arteries. GLS can be used to assess subclinical systolic dysfunction in these patients.Timely intervention can improve LV dysfunction and can even reverse the subclinical changes.