LAUSR

Abstract Aim Novel k21 PLGA nanoparticles (nano-PLGA-RF/VE-TPGS0.50⁞k21) with synergistic effect of VE-TPGS with riboflavin-5-phospshate solution were used to analyze structural integrity, chemical interactions, antimicrobial resistance, mechanical properties as a delivery tool to acid-demineralized dentine-substrates. Materials and Methods Synthesized spherical nano-PLGA ⋮ RF/VE-TPGS0.50⁞k21 were assessed for drug-encapsulation and release, antibacterial-profile, MTT, molecular simulation for MMP-2 and MMP-9 and Raman spectroscopy. Results k21 favoured increase in colloidal-size with positive zeta potential. Bands indicated k21 entrapment as nanoparticles were confined inside tubules with no effect on μTBS. XP-GScores were −2.383 and −4.383 for MMP-2 and -9. HYP liberation recorded with collagenase degradation resistance in nano-PLGA ⋮ RF/VE-TPGS0.50⁞k21 specimens. Conclusion Nano-PLGA ⋮ RF/VE-TPGS0.50⁞k21 specimens exhibited superior antibacterial/antibiofilm effects against cariogenic biofilms after bonding-resins infiltration without adversely affecting bond strength.