LAUSR

The antibacterial materials with biodegradable and biocompatible nature have unveiled novel prospects to combat the bacterial infection, which has always been a troubling and challenging issue in the biomedical field. In this study, chitosan (CS) and Titanium dioxide (TiO2) microparticles were well immobilized on polylactic acid (PLA) mats by electrospinning-electrospraying hybrid technique. The surface morphology, chemical composition and characteristic group of the mats were characterized. The results indicated that CS/TiO2 microparticles were successfully immobilized on the surface of PLA mats. In addition, the antibacterial activity and cytotoxicity of the composite mats were investigated to confirm that the layer-by-layer immobilization of CS/TiO2 microparticles via electrospraying could enhance the antibacterial effect and biocompatibility of the mats. At the same time, the PLA-(CS/TiO2-1.5%)1.5 mats exhibited the best performance in antibacterial effect (up to about 95%) and cell viability (nearly 92% and 95% at 3 d and 5 d). The composite mats have great potential as an effective antibacterial material for the biomedical applications.