LAUSR

Chronic diarrhea is the most common problem in most of the countries with low socio-economic conditions. Hence, efficient therapeutic formulations are required. The present article explores the potential of the gum polysaccharide that itself has an anti-diarrheal activity, to develop the antibiotic drug 'meropenem' carrier, to improve the pharmacotherapy of the diarrhea. The gum based pure and sterile polymeric drug delivery device was prepared by radiation induced crosslinking method. Polymer matrix was characterized by cryo-SEM, AFM, FTIR, 13C NMR, swelling and drug release studies, gel strength, along with some biomedical properties. The slow release was found without a burst effect with non-Fickian diffusion mechanism. It has also been found that polymer was having pore size = 21.73 nm and crosslink density = 5.28 × 10-5mol cm-3 which were synthesized with [HEMA] 4.70 × 10-1 mol/L and irradiation dose 24.62 kGy during copolymerization reaction. The arabinogalactan crosslinked poly(HEMA) polymers were biocompatible, antioxidant and mucoadhesive.