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Topical administration of pullulan gel accelerates skin tissue regeneration by enhancing collagen synthesis and wound contraction in rats

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Abstract Here, we have studied the efficacy of pullulan gel on wound healing by performing biochemical, biophysical and histological investigations. A 2 cm2 open excision wound was made on the dorsum… Click to show full abstract

Abstract Here, we have studied the efficacy of pullulan gel on wound healing by performing biochemical, biophysical and histological investigations. A 2 cm2 open excision wound was made on the dorsum of the rats and topically treated with 500 μL of pullulan gel. The control group was left untreated. The povidone-iodine (PI) ointment treated animals were considered as positive control. The granulation tissues formed were collected at different time point intervals and used for various biochemical, biophysical and histological analyses. Biochemical analyses revealed that pullulan gel significantly (p

Keywords: pullulan gel; administration pullulan; pullulan; gel accelerates; wound; topical administration

Journal Title: International Journal of Biological Macromolecules
Year Published: 2020

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