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Disruptions to the cerebellar GABAergic system in juvenile guinea pigs following preterm birth

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Children that are born preterm are at an increased risk of developing cognitive problems and behavioural disorders, such as attention deficit hyperactivity disorder (ADHD). There is increasing interest in the… Click to show full abstract

Children that are born preterm are at an increased risk of developing cognitive problems and behavioural disorders, such as attention deficit hyperactivity disorder (ADHD). There is increasing interest in the role of the cerebellum in these processes and the potential involvement of GABAergic pathways in neurodevelopmental disorders. We propose that preterm birth, and the associated loss of the trophic intrauterine environment, alters the development of the cerebellum, contributing to ongoing neurobehavioral disorders.

Keywords: disruptions cerebellar; cerebellar gabaergic; gabaergic system; system juvenile; preterm birth; juvenile guinea

Journal Title: International Journal of Developmental Neuroscience
Year Published: 2018

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