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Role of procalcitonin as a predictor of clinical outcomes in hospitalized patients with COVID-19

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Objectives In this study, we aimed to determine the correlation between procalcitonin (PCT) levels and clinical outcomes including in-hospital mortality, ICU length of stay, and hospital length of stay in… Click to show full abstract

Objectives In this study, we aimed to determine the correlation between procalcitonin (PCT) levels and clinical outcomes including in-hospital mortality, ICU length of stay, and hospital length of stay in patients hospitalized with COVID-19. Methods Clinical, laboratory, and demographic data of 223 patients who met inclusion criteria were analyzed. PCT measurements of 0.25 ng/mL and 0.50 ng/mL were used to stratify patients into two mutually exclusive groups Results Patients with PCT above 0.25 ng/mL on admission had significantly elevated APACHE II scores (9 vs. 8; P = 0.042) and CRP levels (111 μg/mL vs. 79 μg/mL; P = 0.007). A multivariable binary logistic regression model demonstrated no relationship between PCT and mortality (OR = 1.00; 95% Cl: 0.97 to 1.02; P = 0.713). Kaplan-Meier analysis revealed no statistical evidence of a difference between PCT groups and hospital length of stay (P = 0.144 for 0.25 ng/mL, P = 0.368 for 0.50 ng/mL) or intensive care unit length of stay (P = 0.986 for 0.25 ng/mL, P = 0.771 for 0.50 ng/mL). Conclusions Elevated PCT levels were associated with severity of illness but did not correlate with in-hospital mortality, hospital length of stay, or ICU length of stay.

Keywords: pct; length; hospital length; procalcitonin; length stay; clinical outcomes

Journal Title: International Journal of Infectious Diseases
Year Published: 2022

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