Abstract An efficient drug delivery system has been prepared using copper phthalocyanine (CuPc) and fluorapatite (CuPc-FAP). This composite showed excellent dispersibility in water compared with pure CuPc. Interestingly, unlike the… Click to show full abstract
Abstract An efficient drug delivery system has been prepared using copper phthalocyanine (CuPc) and fluorapatite (CuPc-FAP). This composite showed excellent dispersibility in water compared with pure CuPc. Interestingly, unlike the CuPc, the CuPc-FAP composite exhibited strong fluorescence emission around 480 nm, which should be attributed to the restriction of intramolecular rotation of CuPc. Drug delivery experiments were carried out using glycine (Gly), histidine (His) and adenine (Aden) as the drug markers. For Gly and His, the suitable adsorption arises from electrostatic interactions between COO- groups of the drug markers and Ca+ ions of CuPc-FAP. Besides, the hydrogen bonds could be form between NH3+ of Gly and His and surface oxygen atoms of the PO4 group of CuPc-FAP. However, FTIR results showed that the C = C group from the six-membered ring of Aden and the NH2 group are the suitable sites for the interaction of Aden with CuPc-FAP. The composite showed interesting properties including pH- and photo-responsive drug release, due to the co-existence of fluorapatite and CuPc, respectively. We hope that CuPc-FAP be a novel promising candidate as water dispersible drug carrier.
               
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